Krystal Gable PA-C, MPAS

Media & Research

Synergies of Ketamine and Psychotherapy
Ketamine for Depression and mood disorders

Ketamine is readily available, is inexpensive to manufacture, and has a relatively good safety profile. It is likely for these reasons that it is the most popular anesthesia drug worldwide, used to induce temporary anesthesia, amnesia, and paralysis. Read full article here.

Ketamine, A transformational Catalyst: MAPS

Yale Scientists explain how ketamine vanquishes depression within hours

Ketamine may regenerate synaptic connections between brain cells damaged by stress and depression, according to new Yale-led research. Read full article here.

Ketamine 50 year in use, from anesthesia to rapid antidepressant effects
Ketamine Treatment for depression: a review
Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy
Currently, ketamine is the only legal psychedelic medicine available to mental health providers for the treatment of emotional suffering. Over the past several years, ketamine has come into psychiatric use as an intervention for treatment resistant depression (TRD), administered intravenously without a psychotherapeutic component. In these settings, ketamine’s psychedelic effects are viewed as undesirable “side … Learn more
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation – where stored memories become briefly labile upon retrieval – may offer a means to disrupt MRMs and prevent relapse. However, reliable means for pharmacologically weakening MRMs in …

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Psychedelic Psychiatry’s Brave New World
After a legally mandated, decades-long global arrest of research on psychedelic drugs, investigation of psychedelics in the context of psychiatric disorders is yielding exciting results. Outcomes of neuroscience and clinical research into 5 Hydroxytryptamine 2A (5-HT2A) receptor agonists, such as psilocybin, show promise for addressing a range of serious disorders, including depression and addiction. Learn more
At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial
At-home Ketamine-assisted therapy (KAT) with psychosocial support and remote monitoring through telehealth platforms addresses access barriers, including the COVID-19 pandemic. Large-scale evaluation of this approach is needed for questions regarding safety and effectiveness for depression and anxiety.